HIGHLIGHTED PAPERS:

PERSPECTIVES IN PHARMACOLOGY:

Miriam Huls, Frans G. M. Russel, and Rosalinde Masereeuw

The Role of ATP Binding Cassette Transporters in Tissue Defense and Organ Regeneration
J Pharmacol Exp Ther 2009 328: 3-9. Published online September 12, 2008; 10.1124/jpet.107.132225 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Mei-Chuan Ko and Stephen M. Husbands

Effects of Atypical -Opioid Receptor Agonists on Intrathecal Morphine-Induced Itch and Analgesia in Primates
J Pharmacol Exp Ther 2009 328: 193-200. Published online October 8, 2008; 10.1124/jpet.108.143925 [Abstract] [Full Text] [PDF]  

Stephan Steidl and John S. Yeomans

M₅ Muscarinic Receptor Knockout Mice Show Reduced Morphine-Induced Locomotion but Increased Locomotion after Cholinergic Antagonism in the Ventral Tegmental Area
J Pharmacol Exp Ther 2009 328: 263-275. Published online October 10, 2008; 10.1124/jpet.108.144824 [Abstract] [Full Text] [PDF]  

N. P. Visanji, S. H. Fox, T. H. Johnston, M. J. Millan, and J. M. Brotchie

₁-Adrenoceptors Mediate Dihydroxyphenylalanine-Induced Activity in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Macaques
J Pharmacol Exp Ther 2009 328: 276-283. Published online October 27, 2008; 10.1124/jpet.108.144097 [Abstract] [Full Text] [PDF]  

Viviana Trezza and Louk J. M. J. Vanderschuren

Divergent Effects of Anandamide Transporter Inhibitors with Different Target Selectivity on Social Play Behavior in Adolescent Rats
J Pharmacol Exp Ther 2009 328: 343-350. Published online October 23, 2008; 10.1124/jpet.108.141069 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Kwang-Seok Oh, Sunkyung Lee, Kyu Yang Yi, Ho Won Seo, Hyun-Na Koo, and Byung Ho Lee

A Novel and Orally Active Poly(ADP-Ribose) Polymerase Inhibitor, KR-33889 [2-[Methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic Acid Amide], Attenuates Injury in in Vitro Model of Cell Death and in Vivo Model of Cardiac Ischemia
J Pharmacol Exp Ther 2009 328: 10-18. Published online October 3, 2008; 10.1124/jpet.108.143719 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ana Belén García-Redondo, Ana María Briones, Amada Elia Beltrán, María Jesús Alonso, Ulf Simonsen, and Mercedes Salaices

Hypertension Increases Contractile Responses to Hydrogen Peroxide in Resistance Arteries through Increased Thromboxane A₂, Ca²⁺, and Superoxide Anion Levels
J Pharmacol Exp Ther 2009 328: 19-27. Published online September 25, 2008; 10.1124/jpet.108.144295 [Abstract] [Full Text] [PDF]  

Noha Nassar and Abdel A. Abdel-Rahman

Brainstem Adenosine A₁ Receptor Signaling Masks Phosphorylated Extracellular Signal-Regulated Kinase 1/2-Dependent Hypotensive Action of Clonidine in Conscious Normotensive Rats
J Pharmacol Exp Ther 2009 328: 83-89. Published online October 10, 2008; 10.1124/jpet.108.143883 [Abstract] [Full Text] [PDF]  

Kazuhiko Seya, Kouta Kanemaru, Chiharu Sugimoto, Megumi Suzuki, Teruko Takeo, Shigeru Motomura, Haruo Kitahara, Masatake Niwa, Yoshiteru Oshima, and Ken-Ichi Furukawa

Opposite Effects of Two Resveratrol (trans-3,5,4'-Trihydroxystilbene) Tetramers, Vitisin A and Hopeaphenol, on Apoptosis of Myocytes Isolated from Adult Rat Heart
J Pharmacol Exp Ther 2009 328: 90-98. Published online October 16, 2008; 10.1124/jpet.108.143172 [Abstract] [Full Text] [PDF]  

Lampson Fan, David Sawbridge, Vinoj George, Lei Teng, Alexis Bailey, Ian Kitchen, and Jian-Mei Li

Chronic Cocaine-Induced Cardiac Oxidative Stress and Mitogen-Activated Protein Kinase Activation: The Role of Nox2 Oxidase
J Pharmacol Exp Ther 2009 328: 99-106. Published online October 24, 2008; 10.1124/jpet.108.145201 [Abstract] [Full Text] [PDF]  

Andrea Cignarella, Chiara Bolego, Valeria Pelosi, Clara Meda, Andrée Krust, Christian Pinna, Rosa Maria Gaion, Elisabetta Vegeto, and Adriana Maggi

Distinct Roles of Estrogen Receptor- and β in the Modulation of Vascular Inducible Nitric-Oxide Synthase in Diabetes
J Pharmacol Exp Ther 2009 328: 174-182. Published online October 2, 2008; 10.1124/jpet.108.143511 [Abstract] [Full Text] [PDF]  

Jennifer M. Hughes, Oliver Wirth, Kristine Krajnak, Roger Miller, Sheila Flavahan, Dan E. Berkowitz, Dan Welcome, and Nicholas A. Flavahan

Increased Oxidant Activity Mediates Vascular Dysfunction in Vibration Injury
J Pharmacol Exp Ther 2009 328: 223-230. Published online October 27, 2008; 10.1124/jpet.108.144618 [Abstract] [Full Text] [PDF]  

David J. Behm, Andrea Ogbonna, Charlene Wu, Cynthia L. Burns-Kurtis, and Stephen A. Douglas

Epoxyeicosatrienoic Acids Function as Selective, Endogenous Antagonists of Native Thromboxane Receptors: Identification of a Novel Mechanism of Vasodilation
J Pharmacol Exp Ther 2009 328: 231-239. Published online October 3, 2008; 10.1124/jpet.108.145102 [Abstract] [Full Text] [PDF]  

Jane Shearer, David L. Severson, Lin Su, Luiz Belardinelli, and Arvinder K. Dhalla

Partial A₁ Adenosine Receptor Agonist Regulates Cardiac Substrate Utilization in Insulin-Resistant Rats in Vivo
J Pharmacol Exp Ther 2009 328: 306-311. Published online October 24, 2008; 10.1124/jpet.108.143594 [Abstract] [Full Text] [PDF]  

Grzegorz Godlewski, László Offertáler, Douglas Osei-Hyiaman, Fong Ming Mo, Judith Harvey-White, Jie Liu, Margaret I. Davis, Li Zhang, Raj K. Razdan, Garry Milman, Pal Pacher, Partha Mukhopadhyay, David M. Lovinger, and George Kunos

The Endogenous Brain Constituent N-Arachidonoyl L-Serine Is an Activator of Large Conductance Ca²⁺-Activated K⁺ Channels
J Pharmacol Exp Ther 2009 328: 351-361. Published online October 15, 2008; 10.1124/jpet.108.144717 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Katherine W. Figueroa, Michael T. Griffin, and Frederick J. Ehlert

Selectivity of Agonists for the Active State of M₁ to M₄ Muscarinic Receptor Subtypes
J Pharmacol Exp Ther 2009 328: 331-342. Published online September 29, 2008; 10.1124/jpet.108.145219 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Daryl C. Drummond, Charles O. Noble, Zexiong Guo, Mark E. Hayes, John W. Park, Ching-Ju Ou, Yun-Long Tseng, Keelung Hong, and Dmitri B. Kirpotin

Improved Pharmacokinetics and Efficacy of a Highly Stable Nanoliposomal Vinorelbine
J Pharmacol Exp Ther 2009 328: 321-330. Published online October 23, 2008; 10.1124/jpet.108.141200 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Kamakshi Sachidanandam, Jim R. Hutchinson, Mostafa M. Elgebaly, Erin M. Mezzetti, Mong-Heng Wang, and Adviye Ergul

Differential Effects of Diet-Induced Dyslipidemia and Hyperglycemia on Mesenteric Resistance Artery Structure and Function in Type 2 Diabetes
J Pharmacol Exp Ther 2009 328: 123-130. Published online October 21, 2008; 10.1124/jpet.108.142612 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Makoto Furonaka, Noboru Hattori, Takuya Tanimoto, Tadashi Senoo, Nobuhisa Ishikawa, Kazunori Fujitaka, Yoshinori Haruta, Akihito Yokoyama, and Nobuoki Kohno

Suplatast Tosilate Prevents Bleomycin-Induced Pulmonary Fibrosis in Mice
J Pharmacol Exp Ther 2009 328: 55-61. Published online October 2, 2008; 10.1124/jpet.108.141721 [Abstract] [Full Text] [PDF]  

Timo Weiland, Markus Weiller, Gerald Künstle, and Albrecht Wendel

Sensitization by 5-Azacytidine toward Death Receptor-Induced Hepatic Apoptosis
J Pharmacol Exp Ther 2009 328: 107-115. Published online September 30, 2008; 10.1124/jpet.108.143560 [Abstract] [Full Text] [PDF]  

Melinda Wuest, Birgit Eichhorn, Marc O. Grimm, Manfred P. Wirth, Ursula Ravens, and Alberto J. Kaumann

Catecholamines Relax Detrusor through β₂-Adrenoceptors in Mouse and β₃-Adrenoceptors in Man
J Pharmacol Exp Ther 2009 328: 213-222. Published online September 26, 2008; 10.1124/jpet.108.142562 [Abstract] [Full Text] [PDF]  

Isamu Yamaguchi, Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Shuichi Kanazashi, and Koji Takeuchi

Risperidone Attenuates Local and Systemic Inflammatory Responses to Ameliorate Diet-Induced Severe Necrotic Pancreatitis in Mice: It May Provide a New Therapy for Acute Pancreatitis
J Pharmacol Exp Ther 2009 328: 256-262. Published online October 1, 2008; 10.1124/jpet.108.141895 [Abstract] [Full Text] [PDF]  

Sunwoo Park, Glen E. P. Ropella, Sean H. J. Kim, Michael S. Roberts, and C. Anthony Hunt

Computational Strategies Unravel and Trace How Liver Disease Changes Hepatic Drug Disposition
J Pharmacol Exp Ther 2009 328: 294-305. Published online October 23, 2008; 10.1124/jpet.108.142497 [Abstract] [Full Text] [PDF] [Data Supplement]   

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Edwin T. Parlevliet, Janny P. Schröder-van der Elst, Eleonora P. M. Corssmit, Kristen Picha, Karyn O'Neil, Vedrana Stojanovic-Susulic, Tatiana Ort, Louis M. Havekes, Johannes A. Romijn, and Hanno Pijl

CNTO736, a Novel Glucagon-Like Peptide-1 Receptor Agonist, Ameliorates Insulin Resistance and Inhibits Very Low-Density Lipoprotein Production in High-Fat-Fed Mice
J Pharmacol Exp Ther 2009 328: 240-248. Published online October 10, 2008; 10.1124/jpet.108.144154 [Abstract] [Full Text] [PDF]  

Kenji Ikemura, Kimihiko Urano, Hiroko Matsuda, Hideki Mizutani, Takuya Iwamoto, and Masahiro Okuda

Decreased Oral Absorption of Cyclosporine A after Liver Ischemia-Reperfusion Injury in Rats: The Contribution of CYP3A and P-Glycoprotein to the First-Pass Metabolism in Intestinal Epithelial Cells
J Pharmacol Exp Ther 2009 328: 249-255. Published online October 8, 2008; 10.1124/jpet.108.145581 [Abstract] [Full Text] [PDF]  

Shyeilla V. Dhuria, Leah R. Hanson, and William H. Frey, II

Novel Vasoconstrictor Formulation to Enhance Intranasal Targeting of Neuropeptide Therapeutics to the Central Nervous System
J Pharmacol Exp Ther 2009 328: 312-320. Published online October 22, 2008; 10.1124/jpet.108.145565 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

C. Hougaard, M. O. Fraser, C. Chien, A. Bookout, M. Katofiasc, B. S. Jensen, F. Rode, J. Bitsch-Nørhave, L. Teuber, K. B. Thor, D. Strøbæk, E. C. Burgard, and L. C. B. Rønn

A Positive Modulator of K_Ca2 and K_Ca3 Channels, 4,5-Dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), Inhibits Bladder Afferent Firing in Vitro and Bladder Overactivity in Vivo
J Pharmacol Exp Ther 2009 328: 28-39. Published online September 26, 2008; 10.1124/jpet.108.143123 [Abstract] [Full Text] [PDF]  

Spencer S. Ericksen, David F. Cummings, Harel Weinstein, and John A. Schetz

Ligand Selectivity of D₂ Dopamine Receptors Is Modulated by Changes in Local Dynamics Produced by Sodium Binding
J Pharmacol Exp Ther 2009 328: 40-54. Published online October 10, 2008; 10.1124/jpet.108.141531 [Abstract] [Full Text] [PDF]  

Manickavasagom Alkondon, Yasco Aracava, Edna F. R. Pereira, and Edson X. Albuquerque

A Single in Vivo Application of Cholinesterase Inhibitors Has Neuron Type-Specific Effects on Nicotinic Receptor Activity in Guinea Pig Hippocampus
J Pharmacol Exp Ther 2009 328: 69-82. Published online October 8, 2008; 10.1124/jpet.108.146068 [Abstract] [Full Text] [PDF]  

Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi, Ming-Chih Crouthamel, Viswanath Devanarayan, Joan Ellis, Amy Espeseth, Adam T. Gates, Samuel L. Graham, Allison R. Gregro, Daria Hazuda, Jerome H. Hochman, Katharine Holloway, Lixia Jin, Jason Kahana, Ming-tain Lai, Janet Lineberger, Georgia McGaughey, Keith P. Moore, Philippe Nantermet, Beth Pietrak, Eric A. Price, Hemaka Rajapakse, Shaun Stauffer, Melissa A. Steinbeiser, Guy Seabrook, Harold G. Selnick, Xiao-Ping Shi, Matthew G. Stanton, John Swestock, Katherine Tugusheva, Keala X. Tyler, Joseph P. Vacca, Jacky Wong, Guoxin Wu, Min Xu, Jacquelynn J. Cook, and Adam J. Simon

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates
J Pharmacol Exp Ther 2009 328: 131-140. Published online October 14, 2008; 10.1124/jpet.108.143628 [Abstract] [Full Text] [PDF] [Data Supplement]   

Betty B. Yao, Gin Hsieh, Anthony V. Daza, Yihong Fan, George K. Grayson, Tiffany Runyan Garrison, Odile El Kouhen, Bradley A. Hooker, Madhavi Pai, Erica J. Wensink, Anita K. Salyers, Prasant Chandran, Chang Z. Zhu, Chengmin Zhong, Keith Ryther, Megan E. Gallagher, Chih-Liang Chin, Ann E. Tovcimak, Vincent P. Hradil, Gerard B. Fox, Michael J. Dart, Prisca Honore, and Michael D. Meyer

Characterization of a Cannabinoid CB₂ Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging
J Pharmacol Exp Ther 2009 328: 141-151. Published online October 17, 2008; 10.1124/jpet.108.145011 [Abstract] [Full Text] [PDF]  

Laxminarayan G. Hegde, Xiao Li Ping, Nina Jochnowitz, and Douglas A. Craig

The Role of Melanin-Concentrating Hormone-1 Receptors in the Voiding Reflex in Rats
J Pharmacol Exp Ther 2009 328: 165-173. Published online October 10, 2008; 10.1124/jpet.108.143495 [Abstract] [Full Text] [PDF]  

Paulianda J. Jones, Ellen C. Merrick, Timothy W. Batts, Nicholas J. Hargus, Yuesheng Wang, James P. Stables, Edward H. Bertram, Milton L. Brown, and Manoj K. Patel

Modulation of Sodium Channel Inactivation Gating by a Novel Lactam: Implications for Seizure Suppression in Chronic Limbic Epilepsy
J Pharmacol Exp Ther 2009 328: 201-212. Published online October 24, 2008; 10.1124/jpet.108.144709 [Abstract] [Full Text] [PDF]  

Maeng-Hee Kang-Park, Brigitte L. Kieffer, Amanda J. Roberts, Marisa Roberto, Samuel G. Madamba, George Robert Siggins, and Scott D. Moore

µ-Opioid Receptors Selectively Regulate Basal Inhibitory Transmission in the Central Amygdala: Lack of Ethanol Interactions
J Pharmacol Exp Ther 2009 328: 284-293. Published online October 14, 2008; 10.1124/jpet.108.140749 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Patrick J. Shaw, Patricia E. Ganey, and Robert A. Roth

Tumor Necrosis Factor Is a Proximal Mediator of Synergistic Hepatotoxicity from Trovafloxacin/Lipopolysaccharide Coexposure
J Pharmacol Exp Ther 2009 328: 62-68. Published online September 26, 2008; 10.1124/jpet.108.143792 [Abstract] [Full Text] [PDF]  

EDITOR'S NOTE:

Rick G. Schnellmann

J Pharmacol Exp Ther 2009 328: 1. [Full Text] [PDF]  

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