6 January 2009

Alan S. Braverman, Larry S. Miller, Anil K. Vegesna, Mansoor I. Tiwana, Ronald J. Tallarida, and Michael R. Ruggieri

Quantitation of the contractile response mediated by two receptors: M₂ and M₃ muscarinic receptor mediated contractions of human gastroesophageal smooth muscle
Published January 6, 2009; doi: 10.1124/jpet.108.148106 [Abstract] [PDF]  

Mia Ericson, Elin Lof, Rosita Stomberg, and Bo Soderpalm

The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system
Published January 6, 2009; doi: 10.1124/jpet.108.147058 [Abstract] [PDF]  

5 January 2009

Chetan P. Hans, Mourad Zerfaoui, Amarjit Naura, Dana Troxclair, Jack P. Strong, Khalid Matrougui, and Hamid Boulares

Thieno[2,3-c]isoquinolin-5-one (TIQ-A), a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high fat diet-fed ApoE-deficient mice: effects on inflammatory markers and lipid content
Published January 5, 2009; doi: 10.1124/jpet.108.145938 [Abstract] [PDF] [Data Supplement]  

2 January 2009

Michael J Beckstead and Tamara J Phillips

Mice selectively bred for high or low alcohol-induced locomotion exhibit differences in dopamine neuron function
Published January 2, 2009; doi: 10.1124/jpet.108.146316 [Abstract] [PDF]  

31 December 2008

Pattipati S. Naidu, Lamont Booker, Benjamin F. Cravatt, and Aron H. Lichtman

Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception
Published December 31, 2008; doi: 10.1124/jpet.108.143487 [Abstract] [PDF]  

30 December 2008

Fernando S. Ramalho, Izabel Alfany-Fernandez, Arani Casillas-Ramirez, Marta Massip-Salcedo, Anna Serafin, Antoni Rimola, Vicente Arroyo, Juan Rodes, Joan Rosello-Catafau, and Carmen Peralta

Are Angiotensin II receptor antagonists useful strategies in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischemia-reperfusion?
Published December 30, 2008; doi: 10.1124/jpet.108.147835 [Abstract] [PDF]  

Ken-ichi Hosoya, Akihide Makihara, Yuki Tsujikawa, Daisuke Yoneyama, Shinobu Mori, Tetsuya Terasaki, Shin-ichi Akanuma, Masatoshi Tomi, and Masanori Tachikawa

Roles of inner Blood-Retinal Barrier Organic Anion Transporter 3 (OAT3) in the Vitreous/Retina-to-Blood Efflux Transport of p-Aminohippuric Acid, Benzylpenicillin, and 6-Mercaptopurine
Published December 30, 2008; doi: 10.1124/jpet.108.146381 [Abstract] [PDF]  

23 December 2008

Satoshi Ishii, Hui-hwa Chang, Hidekatsu Yoshioka, Tatsuo Shimada, Kazuaki Mannen, Yasunori Higuchi, Atsumi Taguchi, and Jian-Qiang Fan

Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease
Published December 23, 2008; doi: 10.1124/jpet.108.149054 [Abstract] [PDF]  

Brenda Gonzalez, Francisco Paz, Leonor Floran, Jorge Aceves, David Erlij, and Benjamin Floran

CANNABINOID AGONISTS STIMULATE [3-H]-GABA RELEASE IN THE GLOBUS PALLIDUS OF THE RAT WHEN GI PROTEIN-RECEPTOR COUPLING IS RESTRICTED. Role of Dopamine D2 receptors
Published December 23, 2008; doi: 10.1124/jpet.108.145425 [Abstract] [PDF]  

22 December 2008

Rajkumar J Sevak, William W Stoops, Lon R Hays, and Craig R Rush

Discriminative-Stimulus and Subject-Rated Effects of Methamphetamine, d-Amphetamine, Methylphenidate, and Triazolam in Methamphetamine-Trained Humans
Published December 22, 2008; doi: 10.1124/jpet.108.147124 [Abstract] [PDF]  

19 December 2008

Sook Wah Yee, James E. Shima, Stephanie Hesselson, Loan Nguyen, Sarah De Val, Rachel J. LaFond, Michiko Kawamoto, Susan J. Johns, Doug Stryke, Pui-Yan Kwok, Thomas E. Ferrin, Brian L. Black, David Gurwitz, Nadav Ahituv, and Kathleen M. Giacomini

Identification and Characterization of Proximal Promoter Polymorphisms in the Human Nucleoside Transporter CNT2 (SLC28A2)
Published December 19, 2008; doi: 10.1124/jpet.108.147207 [Abstract] [PDF]  

Dale S. Edgerton, Alan D. Cherrington, Doss W. Neal, Melanie Scott, Margaret Lautz, Charles H. Hobbs, Chet Leach, Nancy Brown, Jeff Petro, Angelo Del Parigi, and Thomas R. Strack

Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine
Published December 19, 2008; doi: 10.1124/jpet.108.146985 [Abstract] [PDF]  

Florence Sotty, Trine Damgaard, Liliana P. Montezinho, Arne Mork, Christina Kurre Olsen, Christoffer Bundgaard, and Henriette Husum

Antipsychotic-like effect of retigabine, a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission
Published December 19, 2008; doi: 10.1124/jpet.108.146944 [Abstract] [PDF]  

Rong Chen, Cheryse A. Furman, Minjia Zhang, Myung N. Kim, Robert W. Gereau, Michael Leitges, and Margaret E. Gnegy

Protein kinase C is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice
Published December 19, 2008; doi: 10.1124/jpet.108.147959 [Abstract] [PDF]  

Jun-Xu Li, Kenner C. Rice, and Charles P. France

Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) in rhesus monkeys: antagonism and apparent pA₂ analyses
Published December 19, 2008; doi: 10.1124/jpet.108.145458 [Abstract] [PDF]  

Mary W. Walker, Toni D. Wolinsky, Vrej Jubian, Gamini Chandrasena, Huailing Zhong, Xinyan Huang, Silke Miller, Laxminarayan G. Hegde, Douglas A. Marsteller, Mohammad R. Marzabadi, Mariusz Papp, David H. Overstreet, Christophe P.G. Gerald, and Douglas A. Craig

The novel neuropeptide Y Y₅ receptor antagonist Lu AA33810 exerts anxiolytic-like and antidepressant-like effects in rat models of stress-sensitivity
Published December 19, 2008; doi: 10.1124/jpet.108.144634 [Abstract] [PDF]  

16 December 2008

Sean M. Smith, Jason Uslaner, Lihang Yao, Chadwick Mullins, Nathan Surles, Sarah Huszar, Caitlyn McNaughton, Danette Pascarella, Monika Kandebo, Richard Hinchliffe, Tim Sparey, Nicholas J. Brandon, Brian Jones, Shankar Venkatraman, Mary Beth Young, Nancy Sachs, Marlene Jacobson, and Peter H. Hutson

The Behavioral and Neurochemical Effects of a Novel D-Amino Acid Oxidase Inhibitor 4H-thieno [3,2-b] pyrrole-5-carboxylic acid (Compound 8) and D-serine
Published December 16, 2008; doi: 10.1124/jpet.108.147884 [Abstract] [PDF]  

Jun Zhu, Subbu Apparsundaram, and Linda Dwoskin

Nicotinic receptor activation increases [³H]dopamine uptake and cell surface expression of dopamine transporters in rat prefrontal cortex
Published December 16, 2008; doi: 10.1124/jpet.108.147025 [Abstract] [PDF]  

Andrew B. Norman, Mantana K. Norman, William R. Buesing, Michael R. Tabet, Vladimir L. Tsibulsky, and William J. Ball

The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats
Published December 16, 2008; doi: 10.1124/jpet.108.146407 [Abstract] [PDF]  

Aki T. Heikkinen, Jukka Monkkonen, and Timo Korjamo

Kinetics of cellular retention during Caco-2 permeation experiments: Role of lysosomal sequestration and impact on permeability estimates
Published December 16, 2008; doi: 10.1124/jpet.108.145797 [Abstract] [PDF] [Data Supplement]  

15 December 2008

Yolande Cordeaux, Dharmintra Pasupathy, Joanne Bacon, D. Stephen Charnock-Jones, and Gordon C.S. Smith

Characterization of Serotonin Receptors in Pregnant Human Myometrium
Published December 15, 2008; doi: 10.1124/jpet.108.143040 [Abstract] [PDF]  

12 December 2008

Sven-Christian Sensken, Constantin Bode, and Markus H Graler

Accumulation of FTY720 in lymphoid tissues contributes to prolonged efficacy
Published December 12, 2008; doi: 10.1124/jpet.108.148163 [Abstract] [PDF]  

Hao Pan, Partha Mukhopadhyay, Mohanraj Rajesh, Vivek Patel, Bani Mukhopadhyay, Bin Gao, Gyorgy Hasko, and Pal Pacher

Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation and cell death
Published December 12, 2008; doi: 10.1124/jpet.108.147181 [Abstract] [PDF]  

10 December 2008

Hiroshi Matsubara, Motonobu Watanabe, Tsuyoshi Imai, Yoshihiro Yui, Yasuhiro Mizushima, Yoshimi Hiraumi, Yuri Kamitsuji, Ken-ichiro Watanabe, Koichi Nishijo, Junya Toguchida, Tatsutoshi Nakahata, and Souichi Adachi

Involvement of ERK activation in human osteosarcoma cell resistance to the HDAC inhibitor FK228
Published December 10, 2008; doi: 10.1124/jpet.108.147462 [Abstract] [PDF]  

Daniel Fernandes, Regina de Sordi, Leticia Kramer Pacheco, Geisson Marcos Nardi, Bettina Tomio Heckert, Christina Gaspar Villela, Amanda Revoredo Lobo, Christina Barja-Fidalgo, and Jamil Assreuy

LATE BUT NOT EARLY INHIBITION OF SOLUBLE GUANYLATE CYCLASE DECREASES MORTALITY IN A RAT SEPSIS MODEL
Published December 10, 2008; doi: 10.1124/jpet.108.142034 [Abstract] [PDF]  

9 December 2008

Marni Brisson Tierno, Carolyn A. Kitchens, Bethany Petrik, Thomas H. Graham, Peter Wipf, Fengfeng Xu, William Saunders, Brianne S. Raccor, Raghavan Balachandran, Billy W. Day, Jane R. Stout, Claire E. Walczak, Alexander P. Ducruet, Celeste E. Reese, and John S. Lazo

Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C₁
Published December 9, 2008; doi: 10.1124/jpet.108.147330 [Abstract] [PDF] [Data Supplement]  

Jianli Niu, Asim Azfer, Kangkai Wang, Xihai Wang, and Pappachan E. Kolattukudy

Cardiac-targeted expression of soluble Fas attenuates doxorubicin-induced cardiotoxicity in mice
Published December 9, 2008; doi: 10.1124/jpet.108.146423 [Abstract] [PDF]  

Prasun Guha, Anindya Dey, Biswanath Sarkar, Manish V. Dhyani, Subrata Chattopadhyay, and Sandip K. Bandyopadhyay

Improved Anti-ulcer and Anticancer Properties of a trans-Resveratrol Analog in Mice
Published December 9, 2008; doi: 10.1124/jpet.108.145334 [Abstract] [PDF] [Data Supplement]  

John J. Reiners, Miriam Kleinman, Aby Joiakim, and Patricia A Mathieu

The Chemotherapeutic Agents XK469 and SH80 Inhibit Cytokinesis and Promote Polyploidy and Induce Senescence
Published December 9, 2008; doi: 10.1124/jpet.108.144808 [Abstract] [PDF]  

Wenxian Hu, Wayne L. Hofstetter, Xiaoli Wei, Wei Guo, Yanbin Zhou, Abujiang Pataer, Hong Li, Bingliang Fang, and Stephen G. Swisher

Double-Stranded RNA-Dependent Protein Kinase (PKR)-Dependent Apoptosis Induction by a Novel Small Compound
Published December 9, 2008; doi: 10.1124/jpet.108.141754 [Abstract] [PDF] [Data Supplement]  

8 December 2008

Donna M. Klein, Kevin M. Felsenstein, and Douglas E. Brenneman

Cathepsins B and L differentially regulate amyloid precursor protein processing
Published December 8, 2008; doi: 10.1124/jpet.108.147082 [Abstract] [PDF]  

Neal Gould, Carl W. White, and Brian J Day

A role for mitochondrial oxidative stress in sulfur mustard analog CEES-induced lung cell injury and antioxidant protection
Published December 8, 2008; doi: 10.1124/jpet.108.145037 [Abstract] [PDF]  

5 December 2008

Eduardo Oliver, Daniel Marti, Fermi Monto, Nicla Flacco, Lucrecia Moreno, Domingo Barettino, Dolores Ivorra, and Pilar D'Ocon

The impact of ₁-adrenoceptors up-regulation accompanied by the impairment of -adrenergic vasodilatation in hypertension
Published December 5, 2008; doi: 10.1124/jpet.108.146043 [Abstract] [PDF]  

Ganna Tolstanova, Tetyana Khomenko, Xiaoming Deng, Longchuan Chen, Andrzej Tarnawski, Amrita Ahluwalia, Sandor Szabo, and Zsuzsanna Sandor

Neutralizing anti-VEGF antibody reduces severity of experimental ulcerative colitis in rats. Direct evidence for the pathogenic role of VEGF
Published December 5, 2008; doi: 10.1124/jpet.108.145128 [Abstract] [PDF]  

4 December 2008

Sarah Threlfell, Stephen Sammut, Frank Menniti, Christopher Joseph Schmidt, and Anthony R West

Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to stimulation of frontal cortical afferents
Published December 4, 2008; doi: 10.1124/jpet.108.146332 [Abstract] [PDF]  

John Doukas, Lisa Eide, Karin Stebbins, Adrienne Racanelli-Layton, Luis Dellamary, Michael Martin, Elena Dneprovskaia, Glenn Noronha, Lisette M. Acevedo, Richard Soll, Wolfgang Wrasidlo, and David A. Cheresh

Aerosolized Phosphoinositide 3-Kinase /Inhibitor TG100-115 as a Therapeutic Candidate for Asthma and Chronic Obstructive Pulmonary Disease
Published December 4, 2008; doi: 10.1124/jpet.108.144311 [Abstract] [PDF]  

Antonietta Rossi, Rosanna Di Paola, Emanuela Mazzon, Tiziana Genovese, Rocco Caminiti, Placido Bramanti, Carlo Pergola, Andreas Koeberle, Oliver Werz, Lidia Sautebin, and Salvatore Cuzzocrea

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo
Published December 4, 2008; doi: 10.1124/jpet.108.143214 [Abstract] [PDF]  

2 December 2008

Koji Nobe, Taigi Yamazaki, Naoki Tsumita, Terumasa Hashimoto, and Kazuo Honda

Glucose-dependent enhancement of diabetic bladder contraction is associated with a rho kinase-regulated protein kinase C pathway
Published December 2, 2008; doi: 10.1124/jpet.108.144907 [Abstract] [PDF]  

Marianna E. Jung, Andrew M. Wilson, Xiaohua Ju, Yi Wen, Daniel B. Metzger, and James W. Simpkins

Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen preventable manner
Published December 2, 2008; doi: 10.1124/jpet.108.146829 [Abstract] [PDF]  

John Dunlop, Tim Lock, Brian Jow, Fabrizio Sitzia, Steven Grauer, Flora Jow, Angela Kramer, Mark Bowlby, Andrew Randall, Dianne Kowal, Adam Gilbert, Thomas Comery, James LaRocque, Veronica Soloveva, Jon Brown, and Renza Roncarati

Old and New Pharmacology: Positive Allosteric Modulation of the 7 Nicotinic Acetylcholine Receptor by the 5-HT_2B/C Receptor Antagonist SB-206553
Published December 2, 2008; doi: 10.1124/jpet.108.146514 [Abstract] [PDF]  

26 November 2008

Leon D Kluskens, Ad Nelemans, Rick Rink, Louwe de Vries, Anita Meter-Arkema, Yong Wang, Thomas Walther, Anneke Kuipers, Gert N Moll, and Marijke Haas

Angiotensin-(1-7) with thioether-bridge: an ACE-resistant, potent Ang-(1-7) analogue
Published November 26, 2008; doi: 10.1124/jpet.108.146431 [Abstract] [PDF] [Data Supplement]  

Sarah J. Farnsworth, Trent J. Volz, Glen R. Hanson, and Annette E. Fleckenstein

Cocaine Alters Vesicular Dopamine Sequestration and Potassium-Stimulated Dopamine Release: The Role of D2 Receptor Activation
Published November 26, 2008; doi: 10.1124/jpet.108.146159 [Abstract] [PDF]  

25 November 2008

Jin Ren, Zaichuan Mi, Nicolas A Stewart, and Edwin K Jackson

Identification and Quantification of 2',3'-cAMP Release by the Kidney
Published November 25, 2008; doi: 10.1124/jpet.108.146712 [Abstract] [PDF]  

Michael N. Ndengele, Salvatore Cuzzocrea, Emanuela Masini, Maria Cristina Vinci, Emanuela Esposito, Carolina Muscoli, Daniela Nicoleta Petrusca, Vincenzo Mollace, Emanuela Mazzon, Dechun Li, Irina Petrache, George M. Matuschak, and Daniela Salvemini

Spinal Ceramide Modulates the Development of Morphine Antinociceptive Tolerance via Peroxynitrite Mediated Nitroxidative Stress and Neuroimmune Activation
Published November 25, 2008; doi: 10.1124/jpet.108.146290 [Abstract] [PDF]  

Fan Jia, Peter A. Goldstein, and Neil L. Harrison

The Modulation of Synaptic GABA_A Receptors in the Thalamus by Eszopiclone and Zolpidem
Published November 25, 2008; doi: 10.1124/jpet.108.146084 [Abstract] [PDF]  

Xiangying Jiao, Erhe Gao, Yuexing Yuang, Yajing Wang, Wayne Lau, Walter Koch, Xinliang Ma, and Ling Tao

INO-4885, a Peroxynitrite Decomposition Catalyst, Protects the Heart against Reperfusion Injury in Mice
Published November 25, 2008; doi: 10.1124/jpet.108.144352 [Abstract] [PDF]  

24 November 2008

Kylie J Mansfield, Jonathan J Chandran, Kenneth J Vaux, Richard J Millard, Arthur Christopoulos, Fredrick J Mitchelson, and Elizabeth Burcher

Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa
Published November 24, 2008; doi: 10.1124/jpet.108.145508 [Abstract] [PDF]  

21 November 2008

Ulla Seehusen Kruchov van Deurs, Niels Hadrup, Jorgen Soberg Petersen, Sten Christensen, and Thomas E. N. Jonassen

NOP receptor agonist ZP120 induces antinatriuresis in rats by stimulation of amiloride-sensitive sodium reabsorption
Published November 21, 2008; doi: 10.1124/jpet.108.144774 [Abstract] [PDF]  

20 November 2008

Weihong Ma, Hui Hui, Pablo Pelegrin, and Annmarie Surprenant

Pharmacological characterization of pannexin-1 currents expressed in mammalian cells
Published November 20, 2008; doi: 10.1124/jpet.108.146365 [Abstract] [PDF] [Data Supplement]  

Iris Hecht, Rong Jiang, Andre LF Sampaio, Chen Hermesh, Caleb Rutledge, Ronen Shemesh, Amir Toporik, Merav Beiman, Liat Dassa, Hagit Niv, Gady Cojocaru, Arie Zauberman, Galit Rotman, Mauro Perretti, Jakob Vinten-Johansen, and Yossi Cohen

A novel peptide agonist of FPRL1 (ALX) displays anti-inflammatory and cardioprotective effects
Published November 20, 2008; doi: 10.1124/jpet.108.145821 [Abstract] [PDF]  

Jerry J. Buccafusco, J Warren Beach, and Alvin V. Terry

Desensitization of nicotinic acetylcholine receptors as a strategy for drug development
Published November 20, 2008; doi: 10.1124/jpet.108.145292 [Abstract] [PDF]  

Roberta Baetta, Agnese Granata, Monica Canavesi, Nicola Ferri, Lorenzo Arnaboldi, Stefano Bellosta, Pascal Pfister, and Alberto Corsini

Everolimus inhibits monocyte/macrophage migration in vitro and their accumulation in carotid lesions of cholesterol-fed rabbits
Published November 20, 2008; doi: 10.1124/jpet.108.144147 [Abstract] [PDF]  

18 November 2008

Eric G Vajda, Francisco J. Lopez, Peter Rix, Robert Hill, Yanling Chen, Kyoung-Jin Lee, Zhihong O'Brien, William Y Chang, Martin D Meglasson, and Yong-Hee Lee

Pharmacokinetics and pharmacodynamics of LGD-3303, an orally available non-steroidal selective androgen receptor modulator (SARM)
Published November 18, 2008; doi: 10.1124/jpet.108.146811 [Abstract] [PDF]  

Thomas Storme, Alain Deroussent, Lionel Mercier, Elise Prost, Micheline Re, Fabienne Munier, Thierry Martens, Philippe Bourget, Gilles Vassal, Jacques Royer, and Angelo Paci

New ifosfamide analogues designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity
Published November 18, 2008; doi: 10.1124/jpet.108.144170 [Abstract] [PDF]  

14 November 2008

Paul H. Ratz and Amy S. Miner

Role of PKC and Calcium Entry in KCl-Induced Vascular Smooth Muscle Calcium Sensitization and Feed Back Control of Cellular Calcium Levels
Published November 14, 2008; doi: 10.1124/jpet.108.142422 [Abstract] [PDF]  

13 November 2008

Chun Xia Zhao, Xizhen Xu, Yinghua Cui, Peihua Wang, Xin Wei, Shilin Yang, Matthew L. Edin, Darryl C. Zeldin, and Dao Wen Wang

Increased Endothelial Nitric Oxide Synthase Expression Reduces Hypertension and Hyperinsulinemia in Fructose-treated Rats
Published November 13, 2008; doi: 10.1124/jpet.108.143396 [Abstract] [PDF]  

12 November 2008

Lauren Kent, Lucy Smyth, Jonathan Plumb, Chris Clayton, Steve Fox, David Ray, Stuart Farrow, and Dave Singh

Inhibition of LPS Stimulated COPD Macrophage Inflammatory Gene Expression by Dexamethasone and the p38 MAPK Inhibitor SB706504
Published November 12, 2008; doi: 10.1124/jpet.108.142950 [Abstract] [PDF] [Data Supplement]  

Kin-ya Ohta, Yuichiro Imamura, Noriko Okudaira, Ryou Atsumi, Katsuhisa Inoue, and Hiroaki Yuasa

Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones
Published November 12, 2008; doi: 10.1124/jpet.108.142257 [Abstract] [PDF] [Data Supplement]  

10 November 2008

Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Yoshihisa Shitara, and Yuichi Sugiyama

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans
Published November 10, 2008; doi: 10.1124/jpet.108.146647 [Abstract] [PDF]  

Eduardo R. Butelman, Thomas E Prisinzano, Haiteng Deng, Szymon Rus, and Mary Jeanne Kreek

Unconditioned behavioral effects of the powerful -opioid hallucinogen, salvinorin A: Fast onset and entry into cerebrospinal fluid
Published November 10, 2008; doi: 10.1124/jpet.108.145342 [Abstract] [PDF]  

Mythili Yenjerla, Corey Cox, Leslie Wilson, and Mary Ann Jordan

Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics
Published November 10, 2008; doi: 10.1124/jpet.108.143537 [Abstract] [PDF]  

7 November 2008

Nimesh S. A. Patel, Rosanna di Paola, Emanuela Mazzon, Domenico Britti, Christoph Thiemermann, and Salvatore Cuzzocrea

Peroxisome-proliferator activated receptor- contributes to the resolution of inflammation following renal ischemia/reperfusion injury
Published November 7, 2008; doi: 10.1124/jpet.108.146191 [Abstract] [PDF]  

Christopher Regan, Gary Stump, Stefanie Kane, and Joseph Lynch

CGRP Receptor Antagonism Does Not Affect the Severity of Myocardial Ischemia during Atrial Pacing in Dogs with Coronary Artery Stenosis
Published November 7, 2008; doi: 10.1124/jpet.108.144220 [Abstract] [PDF]  

Onkar Kulkarni, Dirk Eulberg, Norma Selve, Stephan Zollner, Ramanjaneyulu Allam, Rahul D Pawar, Stephanie Pfeiffer, Stephan Segerer, Sven Klussmann, and Hans-Joachim Anders

Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice
Published November 7, 2008; doi: 10.1124/jpet.108.142711 [Abstract] [PDF]  

6 November 2008

Michitaka Ogura, Shigeru Nishida, Michiyasu Ishizawa, Kenichi Sakurai, Makoto Shimizu, Sadanori Matsuo, Sadao Amano, Shigeyuki Uno, and Makoto Makishima

Vitamin D₃ Modulates the Expression of Bile Acid Regulatory Genes and Represses Inflammation in Bile Duct-Ligated Mice
Published November 6, 2008; doi: 10.1124/jpet.108.145987 [Abstract] [PDF]  

Panagiota Zania, Despina Gourni, Alfred C. Aplin, Roberto F. Nicosia, Christodoulos S. Flordellis, Michael E. Maragoudakis, and Nikos E. Tsopanoglou

Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis
Published November 6, 2008; doi: 10.1124/jpet.108.145664 [Abstract] [PDF]  

5 November 2008

Elie Simard, Denan Jin, Shinji Takai, Mizuo Miyazaki, Isabelle Brochu, and Pedro D'Orleans-Juste

CHYMASE-DEPENDENT CONVERSION OF BIG ENDOTHELIN-1 IN THE MOUSE IN VIVO
Published November 5, 2008; doi: 10.1124/jpet.108.142992 [Abstract] [PDF]  

4 November 2008

Mary Chebib, Tina Hinton, Katrina L Schmid, Darren Brinkworth, Haohua Qian, Susana Matos, Hye-Lim Kim, Heba Abdel-Halim, Rohan J Kumar, Graham A R Johnston, and Jane R Hanrahan

Novel, potent and selective GABA_C antagonists inhibit myopia development and facilitate learning and memory
Published November 4, 2008; doi: 10.1124/jpet.108.146464 [Abstract] [PDF]  

Soyong Jang, Jae-Chul Jung, Dong Hyun Kim, Jong Hoon Ryu, Yongnam Lee, Mankil Jung, and Seikwan Oh

The neuroprotective effects of benzylideneacetophenone derivatives on excitotoxicity and inflammation via pJAK2/pSTAT3 and MAPK pathways
Published November 4, 2008; doi: 10.1124/jpet.108.144014 [Abstract] [PDF]  

William P. Fawcett, Yasco Aracava, Michael Adler, Edna F. R. Pereira, and Edson X. Albuquerque

Acute toxicity of organophosphorus compounds in guinea pigs is sex and age dependent and cannot be solely accounted for by acetylcholinesterase inhibition
Published November 4, 2008; doi: 10.1124/jpet.108.146639 [Abstract] [PDF]  

Stephanie Dal-Ros, Christian Bronner, Christa Schott, Modou O. Kane, Marta Chataigneau, Valerie B. Schini-Kerth, and Thierry Chataigneau

Angiotensin II-induced hypertension is associated with a selective inhibition of EDHF-mediated responses in the rat mesenteric artery
Published November 4, 2008; doi: 10.1124/jpet.108.145326 [Abstract] [PDF]  

Tatiana F. Gonzalez-Cestari, Brandon J. Henderson, Ryan E. Pavlovicz, Susan B. McKay, Raed A. El-Hajj, Aravinda B. Pulipaka, Crina M. Orac, Damon D. Reed, R Thomas Boyd, Michael X. Zhu, Chenglong Li, Stephen C. Bergmeier, and Dennis B. McKay

Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery
Published November 4, 2008; doi: 10.1124/jpet.108.144576 [Abstract] [PDF]  

3 November 2008

Sharanya Vemula, Karen Roder, Tianzhi Yang, G. Jayarama Bhat, Thomas J. Thekkumkara, and Thomas J. Abbruscato

A functional role for sodium dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation
Published November 3, 2008; doi: 10.1124/jpet.108.146589 [Abstract] [PDF]  

Hiroki Mori, Hiroko Tonai-Kachi, Yasuo Ochi, Yasuhito Taniguchi, Hiroyuki Ohshiro, Nobuyuki Takahashi, Takeshi Aihara, Akiko Hirao, Teruhisa Kato, Minoru Sakakibara, and Yoichi Kurebayashi

PF-03716556, a novel, potent, and selective acid pump antagonist for the treatment of gastro-esophageal reflux disease
Published November 3, 2008; doi: 10.1124/jpet.108.146415 [Abstract] [PDF]  

Rengasamy RM Maran, Ann Thomas, Magen Roth, Zhonghua Shen, Noriko Esterly, David Pinson, Xin Gao, Yawei Zhang, Vadivel Ganapathy, Frank Gonzalez, and Grace L Guo

FXR Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development
Published November 3, 2008; doi: 10.1124/jpet.108.145409 [Abstract] [PDF] [Data Supplement]  

30 October 2008

Edward Perez-Reyes, Amy L. Van Deusen, and Iuliia Vitko

Molecular pharmacology of human Ca_v3.2 T-type Ca²⁺ channels: Block by antihypertensives, antiarrhythmics, and their analogs
Published October 30, 2008; doi: 10.1124/jpet.108.145672 [Abstract] [PDF]  

Hye-Lim Noh, Yunying Hu, Tae-sik Park, Thomas DiCioccio, Andrew J. Nichols, Kazue Okajima, Shunichi Homma, and Ira J. Goldberg

Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat
Published October 30, 2008; doi: 10.1124/jpet.108.136283 [Abstract] [PDF]  

29 October 2008

Cornelia B. Landersdorfer, Debra C. DuBois, Richard R. Almon, and William J. Jusko

Mechanism-Based Modeling of Nutritional and Leptin Influences on Growth in Normal and Type 2 Diabetic Rats
Published October 29, 2008; doi: 10.1124/jpet.108.144766 [Abstract] [PDF]  

Leo Thomas, Moh Tadayyon, and Michael Mark

Chronic Treatment with the Dipeptidyl Peptidase-4 Inhibitor (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356) Increases Basal Glucagon-Like Peptide-1 and Improves Glycemic Control in Diabetic Rodent Models
Published October 29, 2008; doi: 10.1124/jpet.108.143966 [Abstract] [PDF]  

Valeria Camarda, Anna Rizzi, Chiara Ruzza, Silvia Zucchini, Giuliano Marzola, Erika Marzola, Remo Guerrini, Severo Salvadori, Rainer R Reinscheid, Domenico Regoli, and Girolamo Calo'

In vitro and in vivo pharmacological characterization of the neuropeptide S receptor antagonist [D-Cys(tBu)⁵]NPS
Published October 29, 2008; doi: 10.1124/jpet.108.143867 [Abstract] [PDF]  

28 October 2008

Nikolai B. Fedorov, Lisa C. Benson, John Graef, Patrick M. Lippiello, and Merouane Bencherif

DIFFERENTIAL PHARMACOLOGIES OF MECAMYLAMINE ENANTIOMERS: POSITIVE ALLOSTERIC MODULATION AND NON-COMPETITIVE INHIBITION
Published October 28, 2008; doi: 10.1124/jpet.108.146910 [Abstract] [PDF]  

Johanna J. Bogulavsky, Ann M. Gregus, Paul T-H. Kim, Alberto C.S. Costa, Anjali M. Rajadhyaksha, and Charles E. Inturrisi

Deletion of the GluR5 subunit of kainate receptors affects the development of morphine tolerance
Published October 28, 2008; doi: 10.1124/jpet.108.144121 [Abstract] [PDF]  

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