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PERSPECTIVES IN PHARMACOLOGY
BEHAVIORAL PHARMACOLOGY
CARDIOVASCULAR
CELLULAR AND MOLECULAR
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
ENDOCRINE AND DIABETES
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
NEUROPHARMACOLOGY
TOXICOLOGY

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PERSPECTIVES IN PHARMACOLOGY

Jerry J. Buccafusco, J Warren Beach, and Alvin V. Terry: Desensitization of nicotinic acetylcholine receptors as a strategy for drug development
Published November 20, 2008; doi: 10.1124/jpet.108.145292 [Abstract] [PDF]

BEHAVIORAL PHARMACOLOGY

Pattipati S. Naidu, Lamont Booker, Benjamin F. Cravatt, and Aron H. Lichtman: Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception
Published December 31, 2008; doi: 10.1124/jpet.108.143487 [Abstract] [PDF]

Rajkumar J Sevak, William W Stoops, Lon R Hays, and Craig R Rush: Discriminative-Stimulus and Subject-Rated Effects of Methamphetamine, d-Amphetamine, Methylphenidate, and Triazolam in Methamphetamine-Trained Humans
Published December 22, 2008; doi: 10.1124/jpet.108.147124 [Abstract] [PDF]

Jun-Xu Li, Kenner C. Rice, and Charles P. France: Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) in rhesus monkeys: antagonism and apparent pA₂ analyses
Published December 19, 2008; doi: 10.1124/jpet.108.145458 [Abstract] [PDF]

Eduardo R. Butelman, Thomas E Prisinzano, Haiteng Deng, Szymon Rus, and Mary Jeanne Kreek: Unconditioned behavioral effects of the powerful ${kappa}$ -opioid hallucinogen, salvinorin A: Fast onset and entry into cerebrospinal fluid
Published November 10, 2008; doi: 10.1124/jpet.108.145342 [Abstract] [PDF]

CARDIOVASCULAR

Chetan P. Hans, Mourad Zerfaoui, Amarjit Naura, Dana Troxclair, Jack P. Strong, Khalid Matrougui, and Hamid Boulares: Thieno[2,3-c]isoquinolin-5-one (TIQ-A), a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high fat diet-fed ApoE-deficient mice: effects on inflammatory markers and lipid content
Published January 5, 2009; doi: 10.1124/jpet.108.145938 [Abstract] [PDF] [Data Supplement]

Daniel Fernandes, Regina de Sordi, Leticia Kramer Pacheco, Geisson Marcos Nardi, Bettina Tomio Heckert, Christina Gaspar Villela, Amanda Revoredo Lobo, Christina Barja-Fidalgo, and Jamil Assreuy: LATE BUT NOT EARLY INHIBITION OF SOLUBLE GUANYLATE CYCLASE DECREASES MORTALITY IN A RAT SEPSIS MODEL
Published December 10, 2008; doi: 10.1124/jpet.108.142034 [Abstract] [PDF]

Eduardo Oliver, Daniel Marti, Fermi Monto, Nicla Flacco, Lucrecia Moreno, Domingo Barettino, Dolores Ivorra, and Pilar D'Ocon: The impact of ${alpha}$ ₁-adrenoceptors up-regulation accompanied by the impairment of ${beta}$ -adrenergic vasodilatation in hypertension
Published December 5, 2008; doi: 10.1124/jpet.108.146043 [Abstract] [PDF]

Leon D Kluskens, Ad Nelemans, Rick Rink, Louwe de Vries, Anita Meter-Arkema, Yong Wang, Thomas Walther, Anneke Kuipers, Gert N Moll, and Marijke Haas: Angiotensin-(1-7) with thioether-bridge: an ACE-resistant, potent Ang-(1-7) analogue
Published November 26, 2008; doi: 10.1124/jpet.108.146431 [Abstract] [PDF] [Data Supplement]

Xiangying Jiao, Erhe Gao, Yuexing Yuang, Yajing Wang, Wayne Lau, Walter Koch, Xinliang Ma, and Ling Tao: INO-4885, a Peroxynitrite Decomposition Catalyst, Protects the Heart against Reperfusion Injury in Mice
Published November 25, 2008; doi: 10.1124/jpet.108.144352 [Abstract] [PDF]

Iris Hecht, Rong Jiang, Andre LF Sampaio, Chen Hermesh, Caleb Rutledge, Ronen Shemesh, Amir Toporik, Merav Beiman, Liat Dassa, Hagit Niv, Gady Cojocaru, Arie Zauberman, Galit Rotman, Mauro Perretti, Jakob Vinten-Johansen, and Yossi Cohen: A novel peptide agonist of FPRL1 (ALX) displays anti-inflammatory and cardioprotective effects
Published November 20, 2008; doi: 10.1124/jpet.108.145821 [Abstract] [PDF]

Roberta Baetta, Agnese Granata, Monica Canavesi, Nicola Ferri, Lorenzo Arnaboldi, Stefano Bellosta, Pascal Pfister, and Alberto Corsini: Everolimus inhibits monocyte/macrophage migration in vitro and their accumulation in carotid lesions of cholesterol-fed rabbits
Published November 20, 2008; doi: 10.1124/jpet.108.144147 [Abstract] [PDF]

Paul H. Ratz and Amy S. Miner: Role of PKC ${zeta}$ and Calcium Entry in KCl-Induced Vascular Smooth Muscle Calcium Sensitization and Feed Back Control of Cellular Calcium Levels
Published November 14, 2008; doi: 10.1124/jpet.108.142422 [Abstract] [PDF]

Chun Xia Zhao, Xizhen Xu, Yinghua Cui, Peihua Wang, Xin Wei, Shilin Yang, Matthew L. Edin, Darryl C. Zeldin, and Dao Wen Wang: Increased Endothelial Nitric Oxide Synthase Expression Reduces Hypertension and Hyperinsulinemia in Fructose-treated Rats
Published November 13, 2008; doi: 10.1124/jpet.108.143396 [Abstract] [PDF]

Christopher Regan, Gary Stump, Stefanie Kane, and Joseph Lynch: CGRP Receptor Antagonism Does Not Affect the Severity of Myocardial Ischemia during Atrial Pacing in Dogs with Coronary Artery Stenosis
Published November 7, 2008; doi: 10.1124/jpet.108.144220 [Abstract] [PDF]

Panagiota Zania, Despina Gourni, Alfred C. Aplin, Roberto F. Nicosia, Christodoulos S. Flordellis, Michael E. Maragoudakis, and Nikos E. Tsopanoglou: Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis
Published November 6, 2008; doi: 10.1124/jpet.108.145664 [Abstract] [PDF]

Elie Simard, Denan Jin, Shinji Takai, Mizuo Miyazaki, Isabelle Brochu, and Pedro D'Orleans-Juste: CHYMASE-DEPENDENT CONVERSION OF BIG ENDOTHELIN-1 IN THE MOUSE IN VIVO
Published November 5, 2008; doi: 10.1124/jpet.108.142992 [Abstract] [PDF]

Stephanie Dal-Ros, Christian Bronner, Christa Schott, Modou O. Kane, Marta Chataigneau, Valerie B. Schini-Kerth, and Thierry Chataigneau: Angiotensin II-induced hypertension is associated with a selective inhibition of EDHF-mediated responses in the rat mesenteric artery
Published November 4, 2008; doi: 10.1124/jpet.108.145326 [Abstract] [PDF]

Edward Perez-Reyes, Amy L. Van Deusen, and Iuliia Vitko: Molecular pharmacology of human Ca_v3.2 T-type Ca²⁺ channels: Block by antihypertensives, antiarrhythmics, and their analogs
Published October 30, 2008; doi: 10.1124/jpet.108.145672 [Abstract] [PDF]

CELLULAR AND MOLECULAR

Satoshi Ishii, Hui-hwa Chang, Hidekatsu Yoshioka, Tatsuo Shimada, Kazuaki Mannen, Yasunori Higuchi, Atsumi Taguchi, and Jian-Qiang Fan: Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease
Published December 23, 2008; doi: 10.1124/jpet.108.149054 [Abstract] [PDF]

Yolande Cordeaux, Dharmintra Pasupathy, Joanne Bacon, D. Stephen Charnock-Jones, and Gordon C.S. Smith: Characterization of Serotonin Receptors in Pregnant Human Myometrium
Published December 15, 2008; doi: 10.1124/jpet.108.143040 [Abstract] [PDF]

Donna M. Klein, Kevin M. Felsenstein, and Douglas E. Brenneman: Cathepsins B and L differentially regulate amyloid precursor protein processing
Published December 8, 2008; doi: 10.1124/jpet.108.147082 [Abstract] [PDF]

Weihong Ma, Hui Hui, Pablo Pelegrin, and Annmarie Surprenant: Pharmacological characterization of pannexin-1 currents expressed in mammalian cells
Published November 20, 2008; doi: 10.1124/jpet.108.146365 [Abstract] [PDF] [Data Supplement]

Lauren Kent, Lucy Smyth, Jonathan Plumb, Chris Clayton, Steve Fox, David Ray, Stuart Farrow, and Dave Singh: Inhibition of LPS Stimulated COPD Macrophage Inflammatory Gene Expression by Dexamethasone and the p38 MAPK Inhibitor SB706504
Published November 12, 2008; doi: 10.1124/jpet.108.142950 [Abstract] [PDF] [Data Supplement]

CHEMOTHERAPY, ANTIBIOTICS, & GENE THERAPY

Hiroshi Matsubara, Motonobu Watanabe, Tsuyoshi Imai, Yoshihiro Yui, Yasuhiro Mizushima, Yoshimi Hiraumi, Yuri Kamitsuji, Ken-ichiro Watanabe, Koichi Nishijo, Junya Toguchida, Tatsutoshi Nakahata, and Souichi Adachi: Involvement of ERK activation in human osteosarcoma cell resistance to the HDAC inhibitor FK228
Published December 10, 2008; doi: 10.1124/jpet.108.147462 [Abstract] [PDF]

Marni Brisson Tierno, Carolyn A. Kitchens, Bethany Petrik, Thomas H. Graham, Peter Wipf, Fengfeng Xu, William Saunders, Brianne S. Raccor, Raghavan Balachandran, Billy W. Day, Jane R. Stout, Claire E. Walczak, Alexander P. Ducruet, Celeste E. Reese, and John S. Lazo: Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C₁
Published December 9, 2008; doi: 10.1124/jpet.108.147330 [Abstract] [PDF] [Data Supplement]

John J. Reiners, Miriam Kleinman, Aby Joiakim, and Patricia A Mathieu: The Chemotherapeutic Agents XK469 and SH80 Inhibit Cytokinesis and Promote Polyploidy and Induce Senescence
Published December 9, 2008; doi: 10.1124/jpet.108.144808 [Abstract] [PDF]

Wenxian Hu, Wayne L. Hofstetter, Xiaoli Wei, Wei Guo, Yanbin Zhou, Abujiang Pataer, Hong Li, Bingliang Fang, and Stephen G. Swisher: Double-Stranded RNA-Dependent Protein Kinase (PKR)-Dependent Apoptosis Induction by a Novel Small Compound
Published December 9, 2008; doi: 10.1124/jpet.108.141754 [Abstract] [PDF] [Data Supplement]

Thomas Storme, Alain Deroussent, Lionel Mercier, Elise Prost, Micheline Re, Fabienne Munier, Thierry Martens, Philippe Bourget, Gilles Vassal, Jacques Royer, and Angelo Paci: New ifosfamide analogues designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity
Published November 18, 2008; doi: 10.1124/jpet.108.144170 [Abstract] [PDF]

Mythili Yenjerla, Corey Cox, Leslie Wilson, and Mary Ann Jordan: Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics
Published November 10, 2008; doi: 10.1124/jpet.108.143537 [Abstract] [PDF]

ENDOCRINE AND DIABETES

Dale S. Edgerton, Alan D. Cherrington, Doss W. Neal, Melanie Scott, Margaret Lautz, Charles H. Hobbs, Chet Leach, Nancy Brown, Jeff Petro, Angelo Del Parigi, and Thomas R. Strack: Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine
Published December 19, 2008; doi: 10.1124/jpet.108.146985 [Abstract] [PDF]

Koji Nobe, Taigi Yamazaki, Naoki Tsumita, Terumasa Hashimoto, and Kazuo Honda: Glucose-dependent enhancement of diabetic bladder contraction is associated with a rho kinase-regulated protein kinase C pathway
Published December 2, 2008; doi: 10.1124/jpet.108.144907 [Abstract] [PDF]

Eric G Vajda, Francisco J. Lopez, Peter Rix, Robert Hill, Yanling Chen, Kyoung-Jin Lee, Zhihong O'Brien, William Y Chang, Martin D Meglasson, and Yong-Hee Lee: Pharmacokinetics and pharmacodynamics of LGD-3303, an orally available non-steroidal selective androgen receptor modulator (SARM)
Published November 18, 2008; doi: 10.1124/jpet.108.146811 [Abstract] [PDF]

Hye-Lim Noh, Yunying Hu, Tae-sik Park, Thomas DiCioccio, Andrew J. Nichols, Kazue Okajima, Shunichi Homma, and Ira J. Goldberg: Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat
Published October 30, 2008; doi: 10.1124/jpet.108.136283 [Abstract] [PDF]

Cornelia B. Landersdorfer, Debra C. DuBois, Richard R. Almon, and William J. Jusko: Mechanism-Based Modeling of Nutritional and Leptin Influences on Growth in Normal and Type 2 Diabetic Rats
Published October 29, 2008; doi: 10.1124/jpet.108.144766 [Abstract] [PDF]

Leo Thomas, Moh Tadayyon, and Michael Mark: Chronic Treatment with the Dipeptidyl Peptidase-4 Inhibitor (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356) Increases Basal Glucagon-Like Peptide-1 and Improves Glycemic Control in Diabetic Rodent Models
Published October 29, 2008; doi: 10.1124/jpet.108.143966 [Abstract] [PDF]

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Alan S. Braverman, Larry S. Miller, Anil K. Vegesna, Mansoor I. Tiwana, Ronald J. Tallarida, and Michael R. Ruggieri: Quantitation of the contractile response mediated by two receptors: M₂ and M₃ muscarinic receptor mediated contractions of human gastroesophageal smooth muscle
Published January 6, 2009; doi: 10.1124/jpet.108.148106 [Abstract] [PDF] [Data Supplement]

Fernando S. Ramalho, Izabel Alfany-Fernandez, Arani Casillas-Ramirez, Marta Massip-Salcedo, Anna Serafin, Antoni Rimola, Vicente Arroyo, Juan Rodes, Joan Rosello-Catafau, and Carmen Peralta: Are Angiotensin II receptor antagonists useful strategies in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischemia-reperfusion?
Published December 30, 2008; doi: 10.1124/jpet.108.147835 [Abstract] [PDF]

Hao Pan, Partha Mukhopadhyay, Mohanraj Rajesh, Vivek Patel, Bani Mukhopadhyay, Bin Gao, Gyorgy Hasko, and Pal Pacher: Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation and cell death
Published December 12, 2008; doi: 10.1124/jpet.108.147181 [Abstract] [PDF]

Prasun Guha, Anindya Dey, Biswanath Sarkar, Manish V. Dhyani, Subrata Chattopadhyay, and Sandip K. Bandyopadhyay: Improved Anti-ulcer and Anticancer Properties of a trans-Resveratrol Analog in Mice
Published December 9, 2008; doi: 10.1124/jpet.108.145334 [Abstract] [PDF] [Data Supplement]

Ganna Tolstanova, Tetyana Khomenko, Xiaoming Deng, Longchuan Chen, Andrzej Tarnawski, Amrita Ahluwalia, Sandor Szabo, and Zsuzsanna Sandor: Neutralizing anti-VEGF antibody reduces severity of experimental ulcerative colitis in rats. Direct evidence for the pathogenic role of VEGF
Published December 5, 2008; doi: 10.1124/jpet.108.145128 [Abstract] [PDF]

Jin Ren, Zaichuan Mi, Nicolas A Stewart, and Edwin K Jackson: Identification and Quantification of 2',3'-cAMP Release by the Kidney
Published November 25, 2008; doi: 10.1124/jpet.108.146712 [Abstract] [PDF]

Kylie J Mansfield, Jonathan J Chandran, Kenneth J Vaux, Richard J Millard, Arthur Christopoulos, Fredrick J Mitchelson, and Elizabeth Burcher: Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa
Published November 24, 2008; doi: 10.1124/jpet.108.145508 [Abstract] [PDF]

Ulla Seehusen Kruchov van Deurs, Niels Hadrup, Jorgen Soberg Petersen, Sten Christensen, and Thomas E. N. Jonassen: NOP receptor agonist ZP120 induces antinatriuresis in rats by stimulation of amiloride-sensitive sodium reabsorption
Published November 21, 2008; doi: 10.1124/jpet.108.144774 [Abstract] [PDF]

Nimesh S. A. Patel, Rosanna di Paola, Emanuela Mazzon, Domenico Britti, Christoph Thiemermann, and Salvatore Cuzzocrea: Peroxisome-proliferator activated receptor- ${alpha}$ contributes to the resolution of inflammation following renal ischemia/reperfusion injury
Published November 7, 2008; doi: 10.1124/jpet.108.146191 [Abstract] [PDF]

Michitaka Ogura, Shigeru Nishida, Michiyasu Ishizawa, Kenichi Sakurai, Makoto Shimizu, Sadanori Matsuo, Sadao Amano, Shigeyuki Uno, and Makoto Makishima: Vitamin D₃ Modulates the Expression of Bile Acid Regulatory Genes and Represses Inflammation in Bile Duct-Ligated Mice
Published November 6, 2008; doi: 10.1124/jpet.108.145987 [Abstract] [PDF]

Hiroki Mori, Hiroko Tonai-Kachi, Yasuo Ochi, Yasuhito Taniguchi, Hiroyuki Ohshiro, Nobuyuki Takahashi, Takeshi Aihara, Akiko Hirao, Teruhisa Kato, Minoru Sakakibara, and Yoichi Kurebayashi: PF-03716556, a novel, potent, and selective acid pump antagonist for the treatment of gastro-esophageal reflux disease
Published November 3, 2008; doi: 10.1124/jpet.108.146415 [Abstract] [PDF]

Rengasamy RM Maran, Ann Thomas, Magen Roth, Zhonghua Shen, Noriko Esterly, David Pinson, Xin Gao, Yawei Zhang, Vadivel Ganapathy, Frank Gonzalez, and Grace L Guo: FXR Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development
Published November 3, 2008; doi: 10.1124/jpet.108.145409 [Abstract] [PDF] [Data Supplement]

Alan S. Braverman, Larry S. Miller, Anil K. Vegesna, Mansoor I. Tiwana, Ronald J. Tallarida, and Michael R. Ruggieri: Quantitation of the contractile response mediated by two receptors: M₂ and M₃ muscarinic receptor mediated contractions of human gastroesophageal smooth muscle
Published January 6, 2009; doi: 10.1124/jpet.108.148106 [Abstract] [PDF] [Data Supplement]

Fernando S. Ramalho, Izabel Alfany-Fernandez, Arani Casillas-Ramirez, Marta Massip-Salcedo, Anna Serafin, Antoni Rimola, Vicente Arroyo, Juan Rodes, Joan Rosello-Catafau, and Carmen Peralta: Are Angiotensin II receptor antagonists useful strategies in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischemia-reperfusion?
Published December 30, 2008; doi: 10.1124/jpet.108.147835 [Abstract] [PDF]

Hao Pan, Partha Mukhopadhyay, Mohanraj Rajesh, Vivek Patel, Bani Mukhopadhyay, Bin Gao, Gyorgy Hasko, and Pal Pacher: Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation and cell death
Published December 12, 2008; doi: 10.1124/jpet.108.147181 [Abstract] [PDF]

Prasun Guha, Anindya Dey, Biswanath Sarkar, Manish V. Dhyani, Subrata Chattopadhyay, and Sandip K. Bandyopadhyay: Improved Anti-ulcer and Anticancer Properties of a trans-Resveratrol Analog in Mice
Published December 9, 2008; doi: 10.1124/jpet.108.145334 [Abstract] [PDF] [Data Supplement]

Ganna Tolstanova, Tetyana Khomenko, Xiaoming Deng, Longchuan Chen, Andrzej Tarnawski, Amrita Ahluwalia, Sandor Szabo, and Zsuzsanna Sandor: Neutralizing anti-VEGF antibody reduces severity of experimental ulcerative colitis in rats. Direct evidence for the pathogenic role of VEGF
Published December 5, 2008; doi: 10.1124/jpet.108.145128 [Abstract] [PDF]

Jin Ren, Zaichuan Mi, Nicolas A Stewart, and Edwin K Jackson: Identification and Quantification of 2',3'-cAMP Release by the Kidney
Published November 25, 2008; doi: 10.1124/jpet.108.146712 [Abstract] [PDF]

Kylie J Mansfield, Jonathan J Chandran, Kenneth J Vaux, Richard J Millard, Arthur Christopoulos, Fredrick J Mitchelson, and Elizabeth Burcher: Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa
Published November 24, 2008; doi: 10.1124/jpet.108.145508 [Abstract] [PDF]

Ulla Seehusen Kruchov van Deurs, Niels Hadrup, Jorgen Soberg Petersen, Sten Christensen, and Thomas E. N. Jonassen: NOP receptor agonist ZP120 induces antinatriuresis in rats by stimulation of amiloride-sensitive sodium reabsorption
Published November 21, 2008; doi: 10.1124/jpet.108.144774 [Abstract] [PDF]

Nimesh S. A. Patel, Rosanna di Paola, Emanuela Mazzon, Domenico Britti, Christoph Thiemermann, and Salvatore Cuzzocrea: Peroxisome-proliferator activated receptor- ${alpha}$ contributes to the resolution of inflammation following renal ischemia/reperfusion injury
Published November 7, 2008; doi: 10.1124/jpet.108.146191 [Abstract] [PDF]

Michitaka Ogura, Shigeru Nishida, Michiyasu Ishizawa, Kenichi Sakurai, Makoto Shimizu, Sadanori Matsuo, Sadao Amano, Shigeyuki Uno, and Makoto Makishima: Vitamin D₃ Modulates the Expression of Bile Acid Regulatory Genes and Represses Inflammation in Bile Duct-Ligated Mice
Published November 6, 2008; doi: 10.1124/jpet.108.145987 [Abstract] [PDF]

Hiroki Mori, Hiroko Tonai-Kachi, Yasuo Ochi, Yasuhito Taniguchi, Hiroyuki Ohshiro, Nobuyuki Takahashi, Takeshi Aihara, Akiko Hirao, Teruhisa Kato, Minoru Sakakibara, and Yoichi Kurebayashi: PF-03716556, a novel, potent, and selective acid pump antagonist for the treatment of gastro-esophageal reflux disease
Published November 3, 2008; doi: 10.1124/jpet.108.146415 [Abstract] [PDF]

Rengasamy RM Maran, Ann Thomas, Magen Roth, Zhonghua Shen, Noriko Esterly, David Pinson, Xin Gao, Yawei Zhang, Vadivel Ganapathy, Frank Gonzalez, and Grace L Guo: FXR Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development
Published November 3, 2008; doi: 10.1124/jpet.108.145409 [Abstract] [PDF] [Data Supplement]

NEUROPHARMACOLOGY

Mia Ericson, Elin Lof, Rosita Stomberg, and Bo Soderpalm: The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system
Published January 6, 2009; doi: 10.1124/jpet.108.147058 [Abstract] [PDF]

Michael J Beckstead and Tamara J Phillips: Mice selectively bred for high or low alcohol-induced locomotion exhibit differences in dopamine neuron function
Published January 2, 2009; doi: 10.1124/jpet.108.146316 [Abstract] [PDF]

Brenda Gonzalez, Francisco Paz, Leonor Floran, Jorge Aceves, David Erlij, and Benjamin Floran: CANNABINOID AGONISTS STIMULATE [3-H]-GABA RELEASE IN THE GLOBUS PALLIDUS OF THE RAT WHEN GI PROTEIN-RECEPTOR COUPLING IS RESTRICTED. Role of Dopamine D2 receptors
Published December 23, 2008; doi: 10.1124/jpet.108.145425 [Abstract] [PDF]

Florence Sotty, Trine Damgaard, Liliana P. Montezinho, Arne Mork, Christina Kurre Olsen, Christoffer Bundgaard, and Henriette Husum: Antipsychotic-like effect of retigabine, a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission
Published December 19, 2008; doi: 10.1124/jpet.108.146944 [Abstract] [PDF]

Rong Chen, Cheryse A. Furman, Minjia Zhang, Myung N. Kim, Robert W. Gereau, Michael Leitges, and Margaret E. Gnegy: Protein kinase C ${beta}$ is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice
Published December 19, 2008; doi: 10.1124/jpet.108.147959 [Abstract] [PDF]

Mary W. Walker, Toni D. Wolinsky, Vrej Jubian, Gamini Chandrasena, Huailing Zhong, Xinyan Huang, Silke Miller, Laxminarayan G. Hegde, Douglas A. Marsteller, Mohammad R. Marzabadi, Mariusz Papp, David H. Overstreet, Christophe P.G. Gerald, and Douglas A. Craig: The novel neuropeptide Y Y₅ receptor antagonist Lu AA33810 exerts anxiolytic-like and antidepressant-like effects in rat models of stress-sensitivity
Published December 19, 2008; doi: 10.1124/jpet.108.144634 [Abstract] [PDF]

Sean M. Smith, Jason Uslaner, Lihang Yao, Chadwick Mullins, Nathan Surles, Sarah Huszar, Caitlyn McNaughton, Danette Pascarella, Monika Kandebo, Richard Hinchliffe, Tim Sparey, Nicholas J. Brandon, Brian Jones, Shankar Venkatraman, Mary Beth Young, Nancy Sachs, Marlene Jacobson, and Peter H. Hutson: The Behavioral and Neurochemical Effects of a Novel D-Amino Acid Oxidase Inhibitor 4H-thieno [3,2-b] pyrrole-5-carboxylic acid (Compound 8) and D-serine
Published December 16, 2008; doi: 10.1124/jpet.108.147884 [Abstract] [PDF]

Jun Zhu, Subbu Apparsundaram, and Linda Dwoskin: Nicotinic receptor activation increases [³H]dopamine uptake and cell surface expression of dopamine transporters in rat prefrontal cortex
Published December 16, 2008; doi: 10.1124/jpet.108.147025 [Abstract] [PDF]

Andrew B. Norman, Mantana K. Norman, William R. Buesing, Michael R. Tabet, Vladimir L. Tsibulsky, and William J. Ball: The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats
Published December 16, 2008; doi: 10.1124/jpet.108.146407 [Abstract] [PDF]

Sarah Threlfell, Stephen Sammut, Frank Menniti, Christopher Joseph Schmidt, and Anthony R West: Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to stimulation of frontal cortical afferents
Published December 4, 2008; doi: 10.1124/jpet.108.146332 [Abstract] [PDF]

Marianna E. Jung, Andrew M. Wilson, Xiaohua Ju, Yi Wen, Daniel B. Metzger, and James W. Simpkins: Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen preventable manner
Published December 2, 2008; doi: 10.1124/jpet.108.146829 [Abstract] [PDF]

John Dunlop, Tim Lock, Brian Jow, Fabrizio Sitzia, Steven Grauer, Flora Jow, Angela Kramer, Mark Bowlby, Andrew Randall, Dianne Kowal, Adam Gilbert, Thomas Comery, James LaRocque, Veronica Soloveva, Jon Brown, and Renza Roncarati: Old and New Pharmacology: Positive Allosteric Modulation of the ${alpha}$ 7 Nicotinic Acetylcholine Receptor by the 5-HT_2B/C Receptor Antagonist SB-206553
Published December 2, 2008; doi: 10.1124/jpet.108.146514 [Abstract] [PDF]

Sarah J. Farnsworth, Trent J. Volz, Glen R. Hanson, and Annette E. Fleckenstein: Cocaine Alters Vesicular Dopamine Sequestration and Potassium-Stimulated Dopamine Release: The Role of D2 Receptor Activation
Published November 26, 2008; doi: 10.1124/jpet.108.146159 [Abstract] [PDF]

Michael N. Ndengele, Salvatore Cuzzocrea, Emanuela Masini, Maria Cristina Vinci, Emanuela Esposito, Carolina Muscoli, Daniela Nicoleta Petrusca, Vincenzo Mollace, Emanuela Mazzon, Dechun Li, Irina Petrache, George M. Matuschak, and Daniela Salvemini: Spinal Ceramide Modulates the Development of Morphine Antinociceptive Tolerance via Peroxynitrite Mediated Nitroxidative Stress and Neuroimmune Activation
Published November 25, 2008; doi: 10.1124/jpet.108.146290 [Abstract] [PDF]

Fan Jia, Peter A. Goldstein, and Neil L. Harrison: The Modulation of Synaptic GABA_A Receptors in the Thalamus by Eszopiclone and Zolpidem
Published November 25, 2008; doi: 10.1124/jpet.108.146084 [Abstract] [PDF]

Mary Chebib, Tina Hinton, Katrina L Schmid, Darren Brinkworth, Haohua Qian, Susana Matos, Hye-Lim Kim, Heba Abdel-Halim, Rohan J Kumar, Graham A R Johnston, and Jane R Hanrahan: Novel, potent and selective GABA_C antagonists inhibit myopia development and facilitate learning and memory
Published November 4, 2008; doi: 10.1124/jpet.108.146464 [Abstract] [PDF]

Soyong Jang, Jae-Chul Jung, Dong Hyun Kim, Jong Hoon Ryu, Yongnam Lee, Mankil Jung, and Seikwan Oh: The neuroprotective effects of benzylideneacetophenone derivatives on excitotoxicity and inflammation via pJAK2/pSTAT3 and MAPK pathways
Published November 4, 2008; doi: 10.1124/jpet.108.144014 [Abstract] [PDF]

Tatiana F. Gonzalez-Cestari, Brandon J. Henderson, Ryan E. Pavlovicz, Susan B. McKay, Raed A. El-Hajj, Aravinda B. Pulipaka, Crina M. Orac, Damon D. Reed, R Thomas Boyd, Michael X. Zhu, Chenglong Li, Stephen C. Bergmeier, and Dennis B. McKay: Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery
Published November 4, 2008; doi: 10.1124/jpet.108.144576 [Abstract] [PDF]

Sharanya Vemula, Karen Roder, Tianzhi Yang, G. Jayarama Bhat, Thomas J. Thekkumkara, and Thomas J. Abbruscato: A functional role for sodium dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation
Published November 3, 2008; doi: 10.1124/jpet.108.146589 [Abstract] [PDF]

Valeria Camarda, Anna Rizzi, Chiara Ruzza, Silvia Zucchini, Giuliano Marzola, Erika Marzola, Remo Guerrini, Severo Salvadori, Rainer R Reinscheid, Domenico Regoli, and Girolamo Calo': In vitro and in vivo pharmacological characterization of the neuropeptide S receptor antagonist [D-Cys(tBu)⁵]NPS
Published October 29, 2008; doi: 10.1124/jpet.108.143867 [Abstract] [PDF]

Nikolai B. Fedorov, Lisa C. Benson, John Graef, Patrick M. Lippiello, and Merouane Bencherif: DIFFERENTIAL PHARMACOLOGIES OF MECAMYLAMINE ENANTIOMERS: POSITIVE ALLOSTERIC MODULATION AND NON-COMPETITIVE INHIBITION
Published October 28, 2008; doi: 10.1124/jpet.108.146910 [Abstract] [PDF]

Johanna J. Bogulavsky, Ann M. Gregus, Paul T-H. Kim, Alberto C.S. Costa, Anjali M. Rajadhyaksha, and Charles E. Inturrisi: Deletion of the GluR5 subunit of kainate receptors affects the development of morphine tolerance
Published October 28, 2008; doi: 10.1124/jpet.108.144121 [Abstract] [PDF]

TOXICOLOGY

Jianli Niu, Asim Azfer, Kangkai Wang, Xihai Wang, and Pappachan E. Kolattukudy: Cardiac-targeted expression of soluble Fas attenuates doxorubicin-induced cardiotoxicity in mice
Published December 9, 2008; doi: 10.1124/jpet.108.146423 [Abstract] [PDF]

Neal Gould, Carl W. White, and Brian J Day: A role for mitochondrial oxidative stress in sulfur mustard analog CEES-induced lung cell injury and antioxidant protection
Published December 8, 2008; doi: 10.1124/jpet.108.145037 [Abstract] [PDF]

William P. Fawcett, Yasco Aracava, Michael Adler, Edna F. R. Pereira, and Edson X. Albuquerque: Acute toxicity of organophosphorus compounds in guinea pigs is sex and age dependent and cannot be solely accounted for by acetylcholinesterase inhibition
Published November 4, 2008; doi: 10.1124/jpet.108.146639 [Abstract] [PDF]